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Brand Name
Common Name
levonorgestrel intrauterine system
How does this medication work? What will it do for me?

Levonorgestrel belongs to the class of medications called progestins, which is a hormone produced by the ovaries. This is a soft, flexible T-shaped contraceptive (birth control) device that is placed inside the uterus (intrauterine device or IUD). The medication is continuously released over a period of 3 years to prevent pregnancy.

It is used to prevent pregnancy by preventing the lining of the uterus (endometrium) from building up. This makes it very difficult for an egg to be implanted. It also changes the cervical mucus, making it harder for sperm to swim through the cervix.

Levonorgestrel IUD starts to work as soon as it is inserted. However, it is advised to wait 24 to 48 hours before having sexual intercourse.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

This device is placed inside the uterus by your doctor within 7 days after the start of your period. Your doctor will most likely perform a gynecological examination before the device is inserted to examine your uterus for correct placement and to rule out pregnancy or other gynecological conditions that would make using levonorgestrel undesirable.

The device is inserted during a routine office visit with your doctor and only takes a few minutes. You may have to go back to your doctor's office about 4 to 12 weeks after the device is inserted to ensure it is in the right position, and then once a year thereafter or as directed by your doctor. The device can be left in place for up to 3 years, after which you must decide whether to replace the device with a new one or simply to remove the old device.

It is important this medication be used exactly as recommended by your doctor. If you miss an appointment to have a new levonorgestrel-releasing intrauterine device removed or inserted, contact your doctor as soon as possible to reschedule your appointment. After 3 years, this device may not prevent pregnancy.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

What form(s) does this medication come in?

Jaydess is no longer being manufactured for sale in Canada. For brands that may still be available, search under levonorgestrel. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

Who should NOT take this medication?

Do not use this levonorgestrel-releasing intrauterine system if you:

  • are allergic to levonorgestrel or any ingredients or components of the device
  • are or may be pregnant
  • have a bacterial infection of the heart valves (endocarditis)
  • have a previously inserted intrauterine device that has not been removed
  • have an infection of the genital tract
  • have abnormal cells in the cervix
  • have abnormalities of the uterus (e.g., fibroids) that distort the shape of the uterus
  • have acute liver disease or a liver tumour
  • have cancer that responds to progestins (i.e. uterine, cervical or breast cancer)
  • have current or recurrent pelvic inflammatory disease or a a condition that increases the risk of pelvic inflammatory disease
  • have had an abortion complicated by an infection within the past 3 months
  • have inflammation of the cervix or vagina
  • have inflammation of the endometrium (lining of the uterus) after pregnancy within the past 3 months
  • have recently had an abnormal growth of cells inside the uterus
  • have unexplained bleeding of the uterus
What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • acne
  • breast tenderness or pain
  • decreased or absent menstrual bleeding
  • headache
  • infrequent menstrual periods
  • increased menstrual pain
  • oily skin
  • spotting
  • vaginal bleeding

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abdominal or pelvic pain
  • hair loss
  • migraine headache
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • symptoms of vaginal infection (e.g., itching, unusual or increased vaginal discharge)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • dizziness
  • expulsion of device
  • severe lower abdominal pain with bleeding (possible perforation)
  • skin rash, hives
  • symptoms of pregnancy (e.g., abdominal pain, nausea, breast tenderness)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Blood Pressure: Levonorgestrel can cause an increase in blood pressure. If you have high blood pressure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience an increase in your blood pressure after having this device inserted, contact your doctor.

Cigarette smoking: Cigarette smoking is known to increase the risk serious adverse effects on the heart and blood vessels, including blood clots, heart attack, and stroke, potentially causing death. Hormonal contraceptives, such as levonorgestrel, also increase this risk, particularly as a woman gets older. All women are urged not to smoke while using this medication.

Depression: Hormones, such as progestins, are known to contribute to mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking this medication contact your doctor as soon as possible.

Diabetes: Low-dose contraceptives such as this device have very little effect on blood sugar control. However, people with diabetes or those with a family history of diabetes should monitor their blood sugar closely to detect any worsening of blood sugar control.

Ectopic pregnancy: If you have a history of ectopic pregnancy (when a fertilized egg implants itself outside of the uterus), have had surgery on the fallopian tubes, or have had a pelvic infection, you should speak to your doctor or pharmacist before using this device. If you experience lower abdominal pain along with a missed period or unexpected bleeding while using this medication, contact your doctor.

Expulsion of device: Bleeding or pain may indicate that the device has either moved out of position or has been expelled from the uterine cavity. A device that is out of position is less effective and should be removed and replaced by a new device.

Eye problems: Some women may experience a change in vision or contact lens tolerance. If this occurs, contact your eye doctor.

Headache: Levonorgestrel, like other hormones, may cause severe headache or migraine. If you have a history of migraine, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you notice increasing numbers or severity of headaches after the device has been inserted, contact your doctor as soon as possible.

Heart disease: Levonorgestrel may increase the risk of developing blood clots, causing reduced blood flow to organs or the extremities. If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as heart attack, stroke, or clots in the deep veins of your leg. Discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience symptoms such as sharp pain and swelling in the leg, difficulty breathing, chest pain, blurred vision or difficulty speaking, contact your doctor immediately.

Heart valve disorders: This medication can increase your risk of getting an infection in your heart valves if you were born with or have acquired a heart valve defect. You may need to take antibiotics before the insertion and removal of this medication to prevent the infection.

Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Menstrual Bleeding: Some women may experience some pain and bleeding when the device is inserted or removed. Irregular menstrual bleeding is common for the first few months after the device is inserted. Over time, menstrual bleeding decreases and may stop completely while the device is inserted.

Ovarian cysts: This medication can cause the development of ovarian cysts. Most of these don't have any symptoms and disappear on their own within 2 to 3 months. However, if you experience pain in the pelvic area, contact your doctor.

Perforation: The chance of the device puncturing the cervix or uterus is very rare (between 1 in 1,000 and 1 in 10,000). If it were to occur, it would most likely be when the device is being inserted. If this happens, the device should be removed as soon as possible.

Removal of the device: If you experience any of the following, check with your doctor to see if you should have your device removed:

  • confirmed or suspected breast or endometrial cancer
  • migraines or severe headaches
  • recurrent inflammation of the lining of the uterus
  • recurrent pelvic infections
  • significantly elevated blood pressure
  • stroke or heart attack

Sexually transmitted infections (STIs): This device does not protect against STIs, including HIV/AIDS. For protection against STIs, use latex condoms.

Pregnancy: This device should not be used during pregnancy. You should have this device removed as soon as possible if you become pregnant. If it is left in place during pregnancy, the chances of having a miscarriage or premature delivery are increased. The effects of levonorgestrel on a developing infant are not well known, and the risk of harm to the baby cannot be completely ruled out. Removal of this device or probing of the uterus may result in spontaneous abortion. You should check with your doctor about risks to your unborn child.

Breast-feeding: Hormonal birth control, such as this device, is not the first choice of birth control for women who are breast feeding. This medication passes into breast milk. If you are a breast-feeding mother and are using levonorgestrel, it may affect your baby. Some women using this medication have reported decreased milk production. Talk to your doctor about whether you should continue breast-feeding.

Children: Levonorgestrel-releasing intrauterine system is not intended to be used by females who have not yet started menstruating.

What other drugs could interact with this medication?

There may be an interaction between levonorgestrel and any of the following:

  • acitretin
  • apixaban
  • aprepitant
  • argatroban
  • barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
  • benzodiazepines (e.g., alprazolam, clobazam, diazepam, lorazepam)
  • bosentan
  • carbamazepine
  • carfilzomib
  • cholestyramine
  • cobicistat
  • colestipol
  • cyclosporine
  • dabigatran
  • dabrafenib
  • deferasirox
  • diabetes medications (e.g., chlorpropamide, glipizide, glyburide, insulin, metformin, rosiglitazone)
  • efavirenz
  • heparin
  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
  • lamotrigine
  • low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
  • lumacaftor
  • mifepristone
  • mitotane
  • mycophenolate
  • nevirapine
  • oxcarbazepine
  • perampanel
  • phenytoin
  • primidone
  • prucalopride
  • rifabutin
  • rifampin
  • rivaroxaban
  • St. John's wort
  • selegiline
  • thalidomide
  • topiramate
  • tranexamic acid
  • tretinoin
  • ulipristal
  • voriconazole
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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