Propiverine belongs to the class of medications called antispasmodic agents. Propiverine is used to relieve symptoms associated with an overactive bladder, such as urinary urgency (a need to urinate right away), urinary frequency, leakage, or urge incontinence (leaking or wetting caused by an unstoppable urge to urinate).

This medication works by relaxing the muscles in the bladder. It helps to reduce bladder spasms, the urge to pass urine, and the frequency of urination.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

The recommended adult dose of propiverine is 30 mg taken by mouth once daily. If this dose is well tolerated and symptoms have not improved, your doctor may recommend increasing the dose to 45 mg taken once daily. The maximum daily dose is 45 mg.

The 30 mg and 45 mg capsules may be taken with or without food. They release the medication gradually and should be swallowed whole with some water. Do not crush or chew the capsules.

Propiverine is available as 5 mg tablets for children and adolescents. The recommended dose for children is based on body weight, usually calculated by your doctor as 0.8 mg per kilogram of body weight per day, divided into two daily doses. The maximum recommended dose for children or adolescents is 30 mg, taken as 15 mg in the morning and 15 mg in the evening.

The 5 mg tablet form of this medication is affected by food and should be taken at least 1 hour before meals. The tablets should be swallowed whole with a glass of water.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

30 mg
Each orange and white, size 3, modified-release capsule contains 30 mg of white-to-off-white propiverine hydrochloride pellets (equivalent to 27.28 mg propiverine). Nonmedicinal ingredients: ammonio methacrylate copolymer type A, ammonio methacrylate copolymer type B, citric acid, gelatin, lactose monohydrate, magnesium stearate, methacrylic acid-methyl methacrylate copolymer (1:1), methacrylic acid-methyl methacrylate copolymer (1:2), povidone, red iron oxide E172, talc, titanium dioxide E171, triethyl citrate, and yellow iron oxide E172.

45 mg
Each orange size 2, modified-release capsule contains 45 mg of white-to-off-white propiverine hydrochloride pellets (equivalent to 40.92 mg propiverine). Nonmedicinal ingredients: ammonio methacrylate copolymer type A, ammonio methacrylate copolymer type B, citric acid, gelatin, lactose monohydrate, magnesium stearate, methacrylic acid-methyl methacrylate copolymer (1:1), methacrylic acid-methyl methacrylate copolymer (1:2), povidone, red iron oxide E172, talc, titanium dioxide E171, triethyl citrate, and yellow iron oxide E172.

Mictoryl Pediatric

5 mg
Each white, lenticular shape tablet contains 5 mg of propiverine hydrochloride (equivalent to 4.55 mg propiverine). Nonmedicinal ingredients: acacia gum, calcium carbonate, cellulose powdered, glucose monohydrate, kaolin heavy, lactose monohydrate, macrogol 6000, magnesium stearate, silica colloidal anhydrous, sucrose, talc, and titanium dioxide E171.

Do not take this medication if you:

• are allergic to propiverine or any ingredients of the medication
• have a bowel obstruction
• have or may have urinary retention (blocked urine flow)
• have myasthenia gravis
• have decreased muscle tone in the intestines
• have severe ulcerative colitis (inflammation of the digestive tract)
• have toxic megacolon (dilated large intestine)
• have angle-closure glaucoma
• have moderately to severely reduced liver function
• have a fast heartbeat
• have a rare hereditary problem of galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency
• have a rare hereditary problem of fructose intolerance or do not produce enough of the enzyme sucrose-isomaltase

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• changed sense of taste
• constipation
• dizziness
• dry mouth
• fatigue
• flushing
• headache
• heartburn
• itching
• loss of appetite (children)
• nausea
• rash
• sleep disturbance (children)
• tremor
• trouble concentrating (children)
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• confusion
• decreased blood pressure with drowsiness
• difficulty emptying the bladder
• difficulty speaking
• fast or pounding heartbeat
• hallucinations (seeing or hearing things that aren't there)
• restlessness
• vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Abnormal heart rhythms: Propiverine may cause a heart rhythm disturbance called QT prolongation. If you have a history of QT prolongation or are taking certain medications (e.g., amiodarone, sotalol), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Glaucoma: This medication may cause the symptoms of glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking this medication.

Kidney function: If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Lactose intolerance: This medication contains lactose. If you have galactose intolerance (galactosemia, glucose-galactose malabsorption, or Lapp lactase deficiency) you should not take this medication. Talk to your doctor about other alternatives.

Liver function: If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if propiverine passes into breast milk. If you are breast-feeding and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Children generally develop bladder control by the age of 5 years. This medication is not recommended for children earlier than 5 years of age. 

There may be an interaction between propiverine and any of the following:

• aclidinium
• amantadine
• amoxapine
• antihistamines (e.g., bilastine, chlorpheniramine, diphenhydramine, loratadine, rupatadine)
• antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, pimozide, quetiapine, risperidone)
• atropine
• benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
• benztropine
• botulinum toxin
• cannabis
• carbamazepine
• cyclosporine
• darifenacin
• dimenhydrinate
• disopyramide
• domperidone
• eluxadoline
• fesoterodine
• glycopyrrolate
• flibanserin
• ipratropium
• ketotifen
• lemborexant
• lomitapide
• methadone
• metoclopramide
• mirabegron
• monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, tranylcypromine)
• muscle relaxants (e.g., cyclobenzaprine, orphenadrine)
• narcotic pain medications (e.g., codeine, fentanyl, morphine, tramadol)
• nitroglycerin
• oxybutynin
• pilocarpine
• pyridostigmine
• quinidine
• rivastigmine
• scopolamine
• simvastatin
• sirolimus
• solifenacin
• tacrolimus
• thiazide diuretics (e.g., hydrochlorothiazide, indapamide)
• tiotropium
• tolterodine
• topiramate
• tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
• trospium
• umeclidinium

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.